Reproductive tract malformations in patients with impaired male sex development: aspects of laparoscopic correction

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Pkd1 is required for male reproductive tract development

Reproductive tract abnormalities and male infertility have higher incidence in ADPKD patients than in general populations. In this work, we reveal that Pkd1, whose mutations account for 85% of ADPKD cases, is essential for male reproductive tract development. Disruption of Pkd1 caused multiple organ defects in the murine male reproductive tract. The earliest visible defect in the Pkd1(-/-) repr...

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ژورنال

عنوان ژورنال: Andrology and Genital Surgery

سال: 2016

ISSN: 2412-8902,2070-9781

DOI: 10.17650/2070-9781-2016-17-1-44-50